Erectile Dysfunction Treatment
Latest developments for men who can't get an erection for sexual activity: information about the online sale of Sildenafil Citrate (aka Viagra).
In the early days of the internet, the online sale of Viagra was widely promoted - unfortunately, the products offered were often not genuine.
The story of this phase of the sale of these products is described here.
High among the early contenders for the award of "worst online sales company" was Kwikmed. The story of Kwikmed's early days is described here. Its transformation to a legitimate seller of anti-ED drugs, licensed by the state of Utah and apparently fully compliant with all necessary legislation, is fascinating. It now claims (I believe) to be the only licensed online prescriber of Sildenafil in the USA.
And even though a formidable campaign was waged against the original company, resulting in prosecutions and change of ownership, the case has not hampered the growth of online pharmacies, which now operate from all over the world. Unfortunately, many - if not most - of them are fraudulent, as you can read here.
The resolution of this situation is hard to see. There are undoubtedly many men who are being conned out of money for products which are worthless and bogus, men who are desperate for a solution to their erectile problems.
I think it is safe to conclude that there will not be much change to the situation any time soon, even if the USA and European authorities ban the sale of these products, since websites are hard to control when they operate from China, the "ex-Eastern-bloc" countries and Asia. Personal awareness is obviously the key factor: "buyer beware" has never seemed like a more relevant piece of advice.
Viagra does not work for all men, either. There's a significant minority - some estimates put his as high as 20% - of men for whom the drug is ineffective.
A bright spot, possibly, on the horizon is the fact that a respected UK pharmacy, Lloyds, has decided to offer online consultations and sale of Viagra.
One of the latest developments in the search for effective treatments for ED is the use of nanotechnology.
There's been a lot of controversy about the nanotechnology, since the molecules involved are literarily small enough to get into the body cells and affect the biochemistry of the living cell at the molecular level.
But maybe that's not such a bad thing when it comes to erectile dysfunction...for the side effects associated with more traditional drug therapies may be avoided using this revolutionary technology.
Scientists at Yeshiva University's Albert Einstein College of Medicine have encapsulated nitric oxide or prescription drugs using nanomolecules and report that the delivery system works in more than 90% of the recipients - although so far it has only been tested on a limited number of animal species.
Of course, there are many ethical issues associated with testing such a revolutionary and new product on humans, and it may be some time before a definite solution can be put forward for FDA approval, but potentially this discovery means a safer and more effective system of delivery for drugs - right to the point where they are needed.
And ED is no exception - the drugs, be they nitric oxide or Sildenafil Citrate, are delivered exactly where they are needed, and they are released in a controlled manner over a period of time - all of which makes for effective pharmacotherapy.
What's more, the response time to the nanoparticles is rather rapid - a very desirable characteristic of any drug for the treatment of erectile dysfunction!
Watch this space for more information!
http://www.UroToday.com reports on a study into the effect of administering taladafil daily to men with benign prostatic hyperplasia (BPH), who have symptoms such as urinary frequency, intermittency, need to urinate several times a night, straining, incomplete bladder emptying, and a weak urinary flow.
These symptoms and/ or erectile dysfunction (ED) are often seen in the same group of men, particularly ageing men, and they can significantly affect quality of life.
Phosphodiesterase type 5 (PDE5) isozymes are likely to be of use as targets for drug treatments of these conditions of the urogenital tract.
Indeed, the use of the PDE5 inhibitor tadalafil in cases of both BPH and urinary symptoms as well as erectile dysfunction is currently being studied because its half life of 17.5 hours means it can be administered once a day.
In this study, 581 sexually active men were placed in a randomized, placebo-controlled, parallel-group, dose-finding study of BPH-LUTS (lower urinary tract symptoms).
These men also had ED, which was defined as a marked change in erection that negatively affected patient satisfaction with the quality of sexual intercourse.
Changes in erectile function as measured by the International Index of Erectile Function-Erectile Function, changes in BPH-LUTS as measured by the International Prostate Symptom Score, and peak urinary flow rate, and post-urinary residual urinary volume, were measured against various doses of tadalafil administered once daily (2.5 mg, 5 mg, 10 mg, or 20 mg) vs. placebo.
IIEF scores improved at a highly statistically significant level with once-daily tadalafil for all tadalafil groups vs. placebo.
Once-daily tadalafil also improved IIEF-EF scores in men grouped by age, body mass index, severity of symptoms, and prostate-specific antigen (a surrogate marker for prostate size).
Other results studied the effect of taladafil on prior α-blocker use and previous erectile dysfunction therapy, and these studies suggested that administering tadalafil once daily may give good results in a broad group of men with BPH-LUTS.
IPSS improvements were significantly greater with all tadalafil doses vs. placebo.
By contrast, changes in Qmax and PVR were not, unfortunately, clinically meaningful.
All doses of once-daily tadalafil were reasonably well tolerated, with side-effects most commonly reported being headache, back pain, dyspepsia, and myalgia. Tadalafil at 5 mg was the most beneficial dosage.
The study demonstrated that once-daily tadalafil is effective in improving symptoms in men with ED, and also improves signs and symptoms of BPH. Additionally, there are - as might be expected - erectile function improvements which are in line with those found in the general ED population.
The researchers conclude that the use of once-daily tadalafil in men with ED and signs and symptoms of BPH is justified, although no long term effects were measured in this study.